Expression of NF-κBp65 and VEGF in diffuse large B-cell lymphoma and its clinical significance

Objective To study the expression of NF-κBp65,VEGF and its correlation with microvascular density(MVD) in diffuse large B -cell lymphoma(DLBCL) and to evaluate their clinical significance. Methods The expression of NF-κBp65,VEGF and MVD were detected in 58 cases of DLBCL and 10 cases of reactive proliferative lymph node by immunohistochemical technique. Results The positive rate of NF-κBp65 in DLBCL was 58.8% and that of VEGF was 55.2%,but none of them was expressed in reactive proliferative lymph node. The expression of NF-κBp65 was significantly associated with the stage,B syndromes,curative effect,IPI and short survival time(P﹤0.05). At the same time,the expression of VEGF was greatly connected with the stage,curative effect,IPI,LDH and short survival time (P﹤0.05). NF-κBp65 expression was positively related to the expression of VEGF in DLBCL. The mean MVD value in group with NF-κBp65 and VEGF positive expressions was positively significantly than that in the negative group(P﹤0.05). Conclusions The activation of NF-κBp65 contributes to MVD in DLBCL by up-regulation of VEGF,which is closely related to the tumorgenesis and development of DLBCL.