2008•Shandong yiyaoRequires access
Effect of Sheng qi jiang tang ke li on blood glucose,lipid and endothelin-1 expression of the diabetic rats
Yangang Wang
Open publisher page 0 citations
Abstract
Objective To observe the effects of Sheng qi jiang tang ke li on blood glucose,lipid and endothelin-1(ET-1) expression in the diabetic rats.Methods The diabetic rat mode was made,and then experimental groups were randomizedly divided into Sheng qi jiang tang ke li low dose group,mid-dose group,high dose group,rosiglitazone group and control group.When the treatment was effective,the rats' plasma glucose were decreased to normal level or had significant difference compared with control model.The blood glucose,total cholesterin(TC),triglyceride(TG),insulin,ET-1,and ET-1mRNA were measured in different groups.Results After intervention of medicine,the blood glucose,TC,TG,insulin were decreased significantly in Sheng qi jiang tang ke li mid-dose group,high dose group and rosiglitazone group(P0.01).The expressions of ET-1 protein and mRNA of vascular endotheline were also decreased in the rosiglitazone group and high dose group of Sheng qi jiang tang ke li.Conclusions ①Sheng qi jiang tang ke li has effects on anti-diabedic mellitues,the effects present dosage dependence as well.②Sheng qi jiang tang ke li decreases ET-1 expression,and then protects vascluar endothline and cardiac muscle function.