2008•Journal of Hubei Institute for NationalitiesRequires access
Study on mRNA Expression of Blood Vessel Endothelium Monocyte Chemoattractant Protein-1 in Type 2 Diabetic Rat
Ding Xiao-juan
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Abstract
Objective To investigate the expression of blood vessel endothelium monocyte chemoattractant protein-1(MCP-1) in type 2 diabetic rats following Chinese medicine Tang maipingfang.Methods The models of type 2 diabetic Wistar rats were established by injecting high dosage(60mg/kg) of streptozotocin(STZ),and the successful fifty rats were randomly divided into nommal control group,model control group,Privet Tang maipingfang group,Metformin group and xiaokewan group.Measure the weight and blood sugar by cutting the rats tails ever two weeks.After the sixth weeks execute the rats and take the arteriae maxima Galeni.The expression of MCP-1 was assessed by semiquantitative reverse transcriptase(PCR).Results After making modle,the blood sugar was obviously rised and the weight was descend.After post-treatment,Comparing the expression of MCP-1,Privet Tang maipingfang group and Metformin group were obviously descend than modle control group(P0.01).Conclusion Privet Tang maipingfang can decrease the expression of MCP-1mRNA levels,abatement inflammatory reaction of blood vessel endothelium,treatment and decrease arteriosclerotic formation.