2011•Modern Medicine HealthRequires access
Clinical significance of measuring serum IL-18 and NO in chronic severe hepatitis B
Haiyan Wang
Open publisher page 0 citations
Abstract
Objective:To investigate the clinical significance of measuring the levels of serum IL-18 and NO in chronic severe hepatitis B patients.Methods:Serum IL-18 was detected by ELISA method and serum NO by nitrate reductase method in 42 cases of normal control,36 cases of chronic hepatitis B and 31 cases of chronic severe hepatitis B.The levels of serum IL-18 and NO were observed in each group.Results:The levels of serum IL-18 and NO in chronic severe hepatitis B group and chronic hepatitis B group were higher than those in the normal control group.The levels in chronic severe hepatitis B group were increased more significantly compared with chronic hepatitis B group.The comparison among various groups showed significant differences(P0.05).Conclusion:The increasing of serum IL-18 and NO level is one of the reasons for exacerbations of chronic severe hepatitis B.Measuring the serum IL-18 and NO level could be used as the indicator to determine the severity degree of chronic severe hepatitis B patients.