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2004•Zhongguo yaofangRequires access

Pharmacokinetics of Zaleplon Tablets in Chinese Healthy Volunteers

Cui Ma

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Abstract

OBJECTIVE:To study the pharmacokinetics of domestic zaleplon tablets in Chinese healthy volunˉteers.METHODS:20male healthy subjects received a single oral dose of15mg zaleplon tablets.The plasma concentrations of zaleplon were determined by an improved HPLC method.RESULTSCONCLUSION:The main pharmacokinetic parameters of zaleplon were as follow:C max was55.90±16.20ng/ml,T max was1.05±0.32h,Ke was0.74±0.18h -1 ,T 1/2Ke was1.00±0.29h,AUC 0～8 was123.70±25.64ng·h/ml,AUC 0～∞ was125.20±25.80ng·h/ml.The results are comparaˉble to those reported in foreign literature.

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What this paper is about

OBJECTIVE:To study the pharmacokinetics of domestic zaleplon tablets in Chinese healthy volunˉteers.METHODS:20male healthy subjects received a single oral dose of15mg zaleplon tablets.The plasma concentrations of zaleplon were determined by an improved HPLC method.RESULTSCONCLUSION:The main pharmacokinetic parameters of zaleplon were as follow:C max was55.90±16.20ng/ml,T max was1.05±0.32h,Ke was0.74±0.18h -1 ,T 1/2Ke was1.00±0.29h,AUC 0～8 was123.70±25.64ng·h/ml,AUC 0～∞ was125.20±25.80ng·h/ml.The results are comparaˉble to those reported in foreign literature.

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Available abstract

OBJECTIVE:To study the pharmacokinetics of domestic zaleplon tablets in Chinese healthy volunˉteers.METHODS:20male healthy subjects received a single oral dose of15mg zaleplon tablets.The plasma concentrations of zaleplon were determined by an improved HPLC method.RESULTSCONCLUSION:The main pharmacokinetic parameters of zaleplon were as follow:C max was55.90±16.20ng/ml,T max was1.05±0.32h,Ke was0.74±0.18h -1 ,T 1/2Ke was1.00±0.29h,AUC 0～8 was123.70±25.64ng·h/ml,AUC 0～∞ was125.20±25.80ng·h/ml.The results are comparaˉble to those reported in foreign literature.

Key concepts: Pharmacokinetics, Plasma concentration, Pharmacology, Medicine

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