Therapeutic Value of Ulinastatin in Pulmonary Contusion

Objective:To observe the therapeutic value of Ulinastatin in Pulmonary Contusion by comparison between Ulinastatin group and no Ulinastatin group(routine treatment group). Methods: 68 pulmonay contusion patients were randomly divided into routine treatment group (n=34)and Ulinastatin treatment group (n=34). Both groups were given routine treatment, while the patients of the Ulinastatin treatment group were given Ulinastatin (200ku intravenously drip,once every 8 hours, and continued for 6 days)in addition.The efficacy of the therapy in both groups were assessed and serum TNF-α、IL-6 levels were measured on admission and on the fourth and seventh day in both groups. Results:The SIRS markers were not different both in Ulinastatin group and routine treatment group before treatment. TNF-α and IL-6 levels reduced more significantly after treatment in Ulinastatin group than routine group (p0. 05). The Incidence of ARDS was lower in Ulinastatin treatment group than that in routine treatment group (p0. 05). Conclusion:Ulinastatin significantly inhibits the production of inflammatory cytokineses,and effectively prevent PC to proceed to ARDS.