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2012•Journal of Clinical Medicine in PracticeRequires access

Expression and significance of COX-2 in non-small cell lung cancer

Naifu Guan

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Abstract

Objective To study the expression and significance of COX-2 in non-small cell lung cancer(NSCLC).Methods The expression of protein COX-2 was detected by immunohistochemistry technique in 88 NSCLC tissues and 23 normal lung cancer tissues.Results The expression of protein COX-2 in NSCLC was significantly higher than that in normal cancer tissues(P0.01).The expression of protein COX-2 was correlated with the clinical staging and histological type,but was not correlated with the age,sex and transferred lymph node of the patients.Compared with other NSCLC,the expression of protein COX-2 was obviously increased in adenocarcinomas cell carcinomas.Conclusion The expression of protein COX-2 is up-regulated in NSCLC,especially in adenocarcinomas cell carcinomas.The expression of protein COX-2 could be valuable indicators for predicting the prognosis of NSCLC.

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What this paper is about

Objective To study the expression and significance of COX-2 in non-small cell lung cancer(NSCLC).Methods The expression of protein COX-2 was detected by immunohistochemistry technique in 88 NSCLC tissues and 23 normal lung cancer tissues.Results The expression of protein COX-2 in NSCLC was significantly higher than that in normal cancer tissues(P0.01).The expression of protein COX-2 was correlated with the clinical staging and histological type,but was not correlated with the age,sex and transferred lymph node of the patients.Compared with other NSCLC,the expression of protein COX-2 was obviously increased in adenocarcinomas cell carcinomas.Conclusion The expression of protein COX-2 is up-regulated in NSCLC,especially in adenocarcinomas cell carcinomas.The expression of protein COX-2 could be valuable indicators for predicting the prognosis of NSCLC.

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Available abstract

Objective To study the expression and significance of COX-2 in non-small cell lung cancer(NSCLC).Methods The expression of protein COX-2 was detected by immunohistochemistry technique in 88 NSCLC tissues and 23 normal lung cancer tissues.Results The expression of protein COX-2 in NSCLC was significantly higher than that in normal cancer tissues(P0.01).The expression of protein COX-2 was correlated with the clinical staging and histological type,but was not correlated with the age,sex and transferred lymph node of the patients.Compared with other NSCLC,the expression of protein COX-2 was obviously increased in adenocarcinomas cell carcinomas.Conclusion The expression of protein COX-2 is up-regulated in NSCLC,especially in adenocarcinomas cell carcinomas.The expression of protein COX-2 could be valuable indicators for predicting the prognosis of NSCLC.

Key concepts: Medicine, Immunohistochemistry, Lung cancer, Proportional hazards model, Protein expression, Lymph node, Pathology, Cancer

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