2010•Shanxi Yike Daxue xuebaoRequires access

Effect of teramethylpyrazine against cerebral ischemia-reperfusion injury in rats

Fan Jin-ming

Abstract

Objective To explore the effect of teramethylpyrazine against cerebral ischemia-reperfusion injury in rats.Methods Rats were randomly divided into sham operation group(sham group),ischemia-reperfusion group(IR group),teramethylpyrazine group(TMP group).The focal cerebral ischemia reperfusion injury rat model was established by the suture occlusion of Willis ring through the right pterygopalatine segment of artery.The dynamic changes of regional cerebral blood flow(rCBF)and electroencephalogram(EEG)were observed.Serum malondialdehyde(MDA),ATP enzyme(ATPase),endogenous superoxide dismutase(SOD)levels were detected.Results Compared with IR group,the abnormal increase of MDA significantly reduced in TMP group(P0.05),SOD levels in serum and brain tissues and ATP activity increased significantly(P0.05),cerebral blood flow(rCBF)was improved,and the duration of EEG returning to the normal was shortened.Conclusion Teramethylpyrazine has an effect against focal cerebral ischemia-reperfusion injury,which may be induced by reducing focal cerebral ischemia and reperfusion lipid peroxidation,scavenging oxygen free radicals,and extending the blood vessels.

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Key concepts: Ischemia, Malondialdehyde, Medicine, Cerebral blood flow, Anesthesia, Reperfusion injury, Lipid peroxidation, Superoxide dismutase