Effect of L-Amlodipine on ultrastructure of myocardium in dogs with experimental myocardial infarct

This paper investigated the effects of L-Amlodipine on myocardial enzymes and ultrastructure of myocardium in dogs with experimental myocardial infarction. We divided 25 dogs into five groups: (1) control group (2) Amlodipine control group (3) high-dose L-Amlodipine group (4) middle-dose L-Amlodipine group (5) low-dose L-Amlodipine group. An acute myocardial infarction model was made by ligating left anterior descending branch in anesthetic dog. We detected content of myocardial enzymes (AST, CPK, LDH) in blood serum and observed changes of myocardial ultrastructure.The results showed that L-Amlodipine can reduce the ultrastructural injuries of myocardium and diminish the myocardial enzyme activity of blood serum. So we can draw a conclusion that L-Amlodipine might protect cardiac muscle against ischemic myocardial injury.