Study on efficacy of tiopronin combined with metformin in treatment of NAFLD

Objective To study the clinical efficacy of tiopronin and metformin in treatment of NAFLD.Methods Eighty cases of NAFLD were randomly divided into two groups,trial group and control group,each with 40 cases.Patients in trial group were treated with tiopronin and metformin,and patients in control group were only treated with tiopronin,the therapeutic course in both groups was 6 months,and there was no any drug against hepatitis or hyperlipidemia.Clinical manifestations,liver function test and blood level of lipids were observed during the therapeutic course of 6 months,and their clinical efficacy had been evaluated.Results Liver function,blood lipids and insulin resistance were obviously improved after treatment,there was significant difference(P0.05)between these 2 groups.The total effective rate of trial group was 90.0%,and that of control group was 67.5%,the difference between these two groups was significant(P0.05).Conclusion Tiopronin combined with metformin can obviously raise the clinical efficacy in treatment of NAFLD,and this combined therapy is much safer.