Effect of Xinfukang oral liquid on cardiac function in heart failure rats after myocardial infarction

Objective To study the effect of Xinfukangoral liquid(XFK) on cardiac function in heart failure rats after myocardial infarction.Methods SD rats were randomly divided into a modeling group and a sham operation group,the rat model with heart failure after myocardial infarction was established by ligaturing the left anterior descending coronary artery in the modeling group,which was randomly divided into a model group,a trimetazidine group,a high,medium and low-dose XFK group,and continuous intragastric administration was treated in each group for 8 weeks,echcardiography was applied to observe the change of cardiac function in rats after 8 weeks.Results Compared with the sham operation group,LVIDd,LVIDs,LVEDV,LVESV in the model group were significantly increased(P0.01),while EF,FS,CO decreased significantly(P0.01).Compared with the model group,LVIDd,LVIDs,LVEDV,LVESV in the trimetazidine group,the high and low-dose XFK groups were obviously lowered(P0.05 or P0.01),while EF,FS,CO significantly increased(P0.01).Conclusion XFK could improve the cardiac function of heart failure after myocardial infarction in model rat.