2009•Laboratory MedicineRequires access
Study on serum level of sICAM-1 and FVII in patients with acute cerebral infarction and its clinical significance
Yin Meijua
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Abstract
Objective To explore the change of serum level of soluble intercellular adhesion molecule-1(sICAM-1) and coagulative factor Ⅶ(FⅦ) in patients with acute cerebral infarction and its clinicae significance.Methods A total of 34 patients with acute cerebral infarction,28 patients with cerebral insufficiency and 30 healthy subjects were recruited in this study.Serum levels of sICAM-1,FⅦa,FⅦ Ag and FⅦc were measured.Results Serum levels of sICAM-1 were significantly higher in patients with cerebral infarction than in patients with cerebral insufficiency and healthy subjects(P0.01).Serum levels of sICAM-1 were significantly lower in patients with small area of infarction than in patients with middle and large area of infarction(P0.05).Serum levels of FⅦa,FⅦ Ag and FⅦc were significantly higher in patients with cerebral infarction than in the healthy subjects(P0.01).Conclusions Serum levels of sICAM-1,FⅦa,FⅦ Ag and FⅦc are correlated with the progress and severity of cerebral infarction.They can be used as auxiliary diagnostic markers in clinical treatment for cerebral infarction.