Changes of Serum Soluble Adhesive Molecules in Patients with Acute Cerebral Infarction and its Clinical Significance

Objective: To study the changes of serum Soluble Adhesive Molecules in patients with acute cerebral infarction and its clinical significance. Methods: The levels of serum soluble intercellular adhesive molecule-1 (sICAM-1), soluble vascular cell adhesive molecule-1 (sVCAM-1) and soluble E-selectin (sE-selectin) were measured serially with two layer antibody sandwich ELISA in 76 patients with acute cerebral infarction, 52 patients with TIA and 40 normal controls. Results: The levels of serum sICAM-1, sVCAM-1 and sE-selectin in patients with cerebral infarction within 24 hours after the onset were higher than that in patients with TIA and normal controls (P0. 01). The levels of serum sI CAM-1, sVCAM-1 and sE-selectin were higher in the patients with large cerebral infarction than that in patients with medium and small cerebral infarction. The levels of serum sICAM-1. sVCAM-1 and sE-selectin in patients with cerebral infarction increased from 24 hours to 7 days and decreased from 7 days to 14 days. Conclusions: These findings suggest that sICAM-1. sVCAM-1 and sE-selectin are closely related to the development of acute cerebral infarction, and it may play a role in the pathological procedure of cerebral lesions after cerebral ischemia. It may diminish ischemie cerebral lesions to inhibit the expression of adhesive molecules in acute phrase of cerebral infarction.