Clinical study on effect of MACOPB protocol in treatment of refractory or relapsed non-Hodgkin's lymphoma

Objective To investigate the short efficacy and side effects of MACOPB protocol in treatment of the patients with refractory or relapsed non-Hodgkin's lymphoma.Methods A total of 28 patients with refractory or relapsed non-Hodgkin's lymphoma received MACOPB protocol(cyclophosphamide 400 mg/m2 and mitoxantrone 6 mg/m2 given i.v.on weeks 1,3,5,7,9 and 11;methotrexate 400 mg/m2 on weeks 2,6 and 10 followed by leucovorin rescue;vincristine 1.4 mg/m2 on weeks 2,4,6,8,10 and 12;bleomycin 10 mg/m2 on weeks 4,8 and 12 and dexamethasone10 mg for 2 weeks).Results Of all the 28 patients,the overall response rate was78.6%(22/28),the complete response rate was60.7%(17/28),the partial response rate was17.9%(5/28).The main sideeffects were bone marrow suppression,mucositis and gastrointestinal tract reactions.Conclusion MACOPB protocol chemotherapy had a better short efficacy for refractory or relapsed non-Hodgkin's lymphoma and minor sideeffects,which makes a chance for hematopoietic stem cell transplantation.