Curative effect of various doses of glucocorticoid on children in phase 2 of hand-foot-mouth disease

Objective To discuss the therapeutic effect of 3 doses glucocorticoid impaction in the treatment of hand-foot-mouth disease phase 2.Methods The sick children with HFMD of neurological involvement hospitalized from May to July in 2011 were enrolled into the study.All cases received ribavirin and therapies based on their symptoms,while 33 cases received high dose methylprednisolone 10 ~15 mg·kg-1·d-1,24 cases received small methylprednisolone 1~2 mg·kg-1·d-1,and another 24 cases received no methylprednisolone.The curative effect of the three groups were investigated.Results The CNS involvement duration,time of staying in hospital in 3 groups were not significantly different(P0.05).But the febrile duration is shorter in the non-hormone group than those of other groups,which demonstrated a significant difference(P0.05).Eighty-one recruited cased with HFMD of neurological involvement were recovered,and no cases developed into neurogenic pulmonary edema or congestive heart failure during the treatment.Conclusion Small dose glucocorticoid can reduce the fever duration,which lightens the suffering of sick children and anxiety of parents.But glucocorticoid in the therapy of HFMD phase 2 can not shorten the course and improves prognosis.