Preparation of compound Shuxiong pellets with synchronized immediate-release

Objective To prepare compound Shuxiong immediate-release pellets,select the optimal process and formulation,and make various components with vastly different physicochemical properties be released synchronously.Methods Compound Shuxiong immediate release pellets were prepared by extrusion spheronization method.The safflower yellow,ferulic acid and notoginseng saponin used as the index components of release in vitro.The formulation was optimized by influential factors and orthogonal design experiment.Results The three index components were approximately released in the same time through adding compound disintegrating agents(20% effervescent disintegrating agents,5% CMS-Na) and adhesive agents(70% ethanol,2% SDS).Under the simulated gastrointestinal conditions,the in vitro release test of Shuxiong immediate release pellets was carried out.The value of similarity factor(f2) of safflower yellow and notoginseng saponin,safflower yellow and ferulic acid,and notoginseng saponin and ferulic acid was 77.34,58.67,67.83,respectively.The release profiles of various compositions from Shuxiong immediate release pellets showed synchronous-release characteristic and no significant difference between them.Conclusion The results showed that compound Shuxiong pellets prepared by extrusion-spheronization can be disintegrated rapidly through adding in compound disintegrating agents.Various components with vastly different physicochemical properties can be released synchronously.