Preparation of compound Danshen immediate-release pellets by extrusion-spheronization method

Objective To prepare compound Danshen immediate-release pellets and obtain the synchronous release rate of components with significant difference of physicochemical properties.MethodsCompound Danshen immediate-release pellets were prepared by extrusion-spheronization method and the type and amount of the disintegrating agents,adhesive agent,and SDS used in the pellets were screened by regarding salvianolic acid B,PNS,and Borneolum as the three index components of release in vitro.Then the preparation formula was optimized by using orthogonal design.Results The dissolution efficiency(DE)of Borneolum in compound Danshen immediate-release pellets was increased,and the three index components were released synchronistically through adding in 20% effervescent disintegrating agents,5% CMS-Na,and 2% SDS.Conclusion The result shows that the same release rate in immediate-release of the three index components with very different physico-chemical properties of compound Danshen pellets which were prepared by extrusion-spheronization is obtained through adding complex disintegrating agents.