Shuxiong Sustained-release Capsule prepared by multiparticulate site-controlled release technique

Objective To prepare Shuxiong Sustained-release Capsule by multiparticulate site-controlled release technique.Methods First,Shuxiong pellets were prepared with the refined medicinal materials containing in the recipe of Shuxiong Tablets.Then,three kinds of coated pellets were prepared by HPMC,Eudragit L-30D-55,and Eudragit L100-Eudragit S100 combinations(1∶5) as coater,respectively.Finally,Shuxiong Sustained-release Capsules were developed by encapsulating the above three kinds of coated pellets as certain ratio in hard gelatin capsules.Results The three kinds of pellets coated with HPMC,Eudragit L-30D-55 and Eudragit L100-Eudragit S100 combinations(1∶5) could dissolve in any pH condition water,at pH value 5.5 or above and at pH value 6.8 or higher,respectively.The release profiles of notoginseng saponin,safflower yellow,ferulic acid, and tetramethylpyzine from Shuxiong Sustained-release Capsules showed a characteristic of pH-dependent gradient-release in the simulated gastrointestinal pH conditions and no significant difference among them.Conclusion The results indicate that the multiparticulate site-controlled release technique makes it possible that various components with extremely different physicochemical properties in sustained-release formulations of traditional Chinese medicinal compound recipe could release synchronously while sustained-releasing.That complies with the whole conception of formulated compatibility of traditional Chinese medicinal compound recipe.