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Quantitative Determination of Ferulic Acid in the Wumeitougu Oral Liquid with HPLC

Liu Gaofen

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Abstract

OBJECTIVE: To study the quantitative determination method of ferulic acid in the Wumeitougu oral liquid, compare the stability of ferulic acid in different solvents. METHODS:The detecting conditions of RP -- HPLC were as follow Kromasil C_(18) column(4.6mm×200mm, 5μm); mobile phase: methanol-- water(30:70); flow rate: 1ml/ min: detecting was length: 324nm. RESULTS: The calibration curve revealed linearity in the range of 0.05～1.0μg(r=0.9 999). The mean re? ery was 97.01%～101.53%. RSD1.74% (n=3). Ferulic acid was more stable in the mixed solvent without acetic acid(m? anol:water was 1:4) .CONCLUSION:The detecting method is simple, rapid and satisfactory in Tepeatability, and can be ? for quality control of Wumeitougu oral liquid.

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What this paper is about

OBJECTIVE: To study the quantitative determination method of ferulic acid in the Wumeitougu oral liquid, compare the stability of ferulic acid in different solvents. METHODS:The detecting conditions of RP -- HPLC were as follow Kromasil C_(18) column(4.6mm×200mm, 5μm); mobile phase: methanol-- water(30:70); flow rate: 1ml/ min: detecting was length: 324nm. RESULTS: The calibration curve revealed linearity in the range of 0.05～1.0μg(r=0.9 999). The mean re? ery was 97.01%～101.53%. RSD1.74% (n=3). Ferulic acid was more stable in the mixed solvent without acetic acid(m? anol:water was 1:4) .CONCLUSION:The detecting method is simple, rapid and satisfactory in Tepeatability, and can be ? for quality control of Wumeitougu oral liquid.

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Available abstract

OBJECTIVE: To study the quantitative determination method of ferulic acid in the Wumeitougu oral liquid, compare the stability of ferulic acid in different solvents. METHODS:The detecting conditions of RP -- HPLC were as follow Kromasil C_(18) column(4.6mm×200mm, 5μm); mobile phase: methanol-- water(30:70); flow rate: 1ml/ min: detecting was length: 324nm. RESULTS: The calibration curve revealed linearity in the range of 0.05～1.0μg(r=0.9 999). The mean re? ery was 97.01%～101.53%. RSD1.74% (n=3). Ferulic acid was more stable in the mixed solvent without acetic acid(m? anol:water was 1:4) .CONCLUSION:The detecting method is simple, rapid and satisfactory in Tepeatability, and can be ? for quality control of Wumeitougu oral liquid.

Key concepts: Ferulic acid, Chromatography, High-performance liquid chromatography, Chemistry, Calibration curve, Acetic acid, Solvent, Methanol

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