Expressions of E-cadherin and nm23-H_1 are Associated with Invasion andMetastasis of Human Gastric Carcinomas

Objective To evaluate the roles of the expressions of E-cadherin and nm23-H_1 in the invasion and metastasis of human gastric carcinomas.Methods The expression of E-cadherin and nm23-H_1 was analyzed by SP immunohistochemical technique nm23-H_1 in 46 paraffin-embeded tissue specimens of gastric carcinomas.Results 54.3% (25/46) of the primary tumors showed reduced E-cadherin expressions,No significant correlation was found between E-cadherin expressions and tumor diameter,depth of invasion,clinic pathologic stage (P0.05),significant correlation was observed between E-cadherin expression and lymph node metastasis,borrmann classification(P0.05),50% (12/24) of the cases showed stronger E-cadherin immunoreactivity in lymph node metastasis than in primary lesion.45.7% (21/46) of the primary tumors showed reduced nm23-H_1,no significant correlation was found between nm23-H_1 expression and borrmann classification,clinic pathology grade (P0.05),significant correlation was observed between nm23-H_1 expression and tumor diameter,depth of invasion,clinic pathology stage,lymph node metastasis (P0.05),54.5% (25/46) of cases showed stronger nm23-H_1 immunoreactivity in primary lesion than in lymphnode metastasis.There is no relationship between E-cadherin and nm23-H_1.Conclusion E-cadherin and nm-H1 play important role in suppressing gastric cancer invasion and metastasis,but there is no inner relationship between them in gastric cancer.It's affection in suppressing gastric cancer invasion and metastasis may be associated with different period.