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2003•Bulletin of Chinese CancerRequires access

Inhbition of Angiogenesis on CAM by Hydroxycamptothecin

Liu Jian-ping

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Abstract

The study was to reveal the inhibition of angiogenesis on CAM by Hydroxy-cam-ptothecin(HCPT).Gelatin sponges were implanted on top of CAM when chick embryos developed on day8,vessels which towards gelatin and microvascular density(MVD)in gelatin were counted.On CAM model,numbers of vessels at the sponge-CAM boundary and MVD were sig-nificantly different to control(P0.01).[Conclusion]HCPT exerts great efficacy of antiangiogenesis,which can in hibit angiogenesis on CAM model in low concentration.

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What this paper is about

The study was to reveal the inhibition of angiogenesis on CAM by Hydroxy-cam-ptothecin(HCPT).Gelatin sponges were implanted on top of CAM when chick embryos developed on day8,vessels which towards gelatin and microvascular density(MVD)in gelatin were counted.On CAM model,numbers of vessels at the sponge-CAM boundary and MVD were sig-nificantly different to control(P0.01).[Conclusion]HCPT exerts great efficacy of antiangiogenesis,which can in hibit angiogenesis on CAM model in low concentration.

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Available abstract

The study was to reveal the inhibition of angiogenesis on CAM by Hydroxy-cam-ptothecin(HCPT).Gelatin sponges were implanted on top of CAM when chick embryos developed on day8,vessels which towards gelatin and microvascular density(MVD)in gelatin were counted.On CAM model,numbers of vessels at the sponge-CAM boundary and MVD were sig-nificantly different to control(P0.01).[Conclusion]HCPT exerts great efficacy of antiangiogenesis,which can in hibit angiogenesis on CAM model in low concentration.

Key concepts: Angiogenesis, Gelatin, Chemistry, Pharmacology, Cancer research, Medicine, Biochemistry

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