Determination of Soluble E-slectin and Ox-LDL in the Patients with Coronary Artery Disease

Objictive: To evaluate the role of soluble E-selectin and Ox-LDL in different coronary heart disease and the normal and to investigate the relationship of the both with the development of coronary heart disease.Methods: 90 cases of coronary heart disease were divided into the acute myocardial infarction group(30 cases),the unstable angina group(30 cases) and stable angina group(30 cases),with 30 normal controls.Serum level of solube E-selectin and Ox-LDL was measured by enzyme-linked immunosorbent assay.The differences in soluble E-selectin level and Ox-LDL level between different groups were observed.Pearson correlation analysis test was used to analyze the relationship between the level of soluble E-selectin and the level of Ox-LDL.Results: The levels of soluble E-selectin and Ox-LDL were elevated in AMI,UAP and SAP groups as compared with the control group(P0.01).Compared with SAP group,the level of soluble E-selectin and Ox-LDL were elevated in AMI and UAP groups(P0.01),while there is no significant difference between AMI and UAP groups.The levels of soluble E-selectin were correlated with the levels of Ox-LDL in different coronary heart disease.Conclusion: The serious degree of coronary heart disease will be predicted by the levels of soluble E-selectin and Ox-LDL in serum.The development of coronary heart disease can be foreseen.The levels of soluble E-selectin and the levels of Ox-LDL in serum can act as a assistant method for the diagnosis of coronary heart disease.