Effect of Astragalus Polysaccharide on Physiological and Biochemical Indexes in Exhausted Swimming Mice

Pouring different dosages of APS(0.4,0.2,0.1 mg/ml)to exhausted swimming mice's stomach,we analysed blood component and tested the activities of SOD,GSH-Px,CAT.The results showed that the time of swim to exhaust in the high-dose group was extremely remarkably prolonged(P0.01),and that in the middle dose group was significantly prolonged(P0.05);the total number of WBC,Gran% in the high-dose group were significantly lower than those in the control group(P0.01),Lym%,Mid% and Gran were very significantly higher than those in the control group(P0.01),the concentration of HGB and HCT in the high-dose group and sino-dose group were very significantly higher than those in the control group(P0.01);Lym% and Mid% in the sino-dose group were significantly higher than those in the control group(P0.05);the activity of SOD and CAT were significantly increased in the high-dose group and the activity of GSH-PX was very significant decreased(P0.01);the activity of SOD in the sino-dose group was significantly increased(P0.05);the activity of AST and CK in the high-dose group and sino-dose group were very significantly decreased(P0.01).Thus,APS has obvious oxidative damage effects.