Effect of administration of magnesium isoglycyrrhizinate combined with splenectomy on a rat model of acute hepatic failure induced by major liver resection

Objective To investigate the effect of administration of magnesium isoglycyrrhizinate combined with splenectomy on rats with subtotal hepatectomy. Methods 50 SD rats were randomly divided into five groups:85% hepatectomy control group (group A), 85% hepatectomy with splenectomy group (group B),treated with magnesium isoglycyrrhizinate group (group C), treated with magnesium isoglycyrrhizinate combined with splenectomy group (group D) and the sham operation group(group E). The rats in group C and D were intraperitoneally injected with magnesium isoglycyrrhizinate (100 μg/ml)1 ml/100 g,while the other groups injected with normal saline. The changes of plasma ALT and AST, portal venous pressure were recorded and the liver pathological examination were screened post-operation. Results The ALT and AST and portal venous pressure in treatment groups were significantly lower than those in 85% hepatectomy group at 24 h and 48 h post-operation(P0.05). But there were no such differences between group A and group C(P0.05). Conclusions Administration of magnesium isoglycyrrhizinate combined with splenectomy might prevent the acute hepatic failure induced by 85% hepatectomy on rat,and its possible mechanism might relate to the decreasing portal vein pressure and alleviating the residual hepatic cell injury.