Expression of K-ras and PTEN in endometrial carcinoma under 45-year-old younger women

【Objective】 To study the expressions and relationship among K-ras and PTEN in endometrial carcinoma under 45 of age.【Methods】 Selected 66 cases uterine specimens which were excised for uterine diseases,including 42 cases of endometrial carcinoma,6 cases of atypical endometrial hyperplasia and 18 cases of normal endometrium.The expression of K-ras and PTEN in the tissues of endometrium was detected by the immunohistochemical method.【Results】 The expression of K-ras in atypical endometrial hyperplasia and endometrial carcinoma is much higher than that in normal endometrium(P 0.05).Compared with normal endometrium(16.67%),the negative rates of PTEN in atypical endometrial hyperplasia(66.67%) and endometrial carcinoma(85.71%) increased significantly(P 0.005).The expression of K-ras and PTEN has very little do to with clinical stages,histological grades,myometrial invasion depth and lymphatic metastasis.In endometrial carcinoma group,there was no correlation between the expressions of K-ras and PTEN(rs=0.187,P 0.05).The positive expression of K-ras had inconsistency with PTEN.【Conclusions】 These results suggest that the abnormal expression of K-ras and PTEN might be a valuable index for the diagnosis of endometrial carcinoma in the early stage for the patients under 45 years old.