Correlation between Vascular Endothelial Growth Factor and Spiral CT Perfusion Imaging in Colorectal Carcinoma

Objective To evaluate the correlation between vascular endothelial growth factor (VEGF) and spiral CT perfusion imaging in colorectal carcinoma.Materials and Methods Dynamic contrast enhanced spiral CT was performed in 30 patients with pathologically verified colorectal carcinoma. Time density curves (TDC) were created from the region of interest drawn over the tumor, target artery by spiral CT with perfusion functional software. The parameters were measured including: peak height (PH), peak time (PT), mean transit time (MTT), contrast enhancement ratio (CER) and perfusion (PF). VEGF was evaluated by using immunohistochemical staining of surgical specimens with anti VEGF monoclonal antibody, and then VEGF was compared with parameters of spiral CT perfusion. The correlation between VEGF, the parameters and clinicopathological factors (Dukes' stages, depth of invasion and lymph node metastasis) was also studied. Results The positive rate of VEGF expression was 87%, there was no significant correlation between the VEGF expression and the parameters of spiral CT perfusion (P0.05). VEGF and the perfusion parameters were not associated with invasive depth, metastasis and disease stage.Conclusion Both VEGF and spiral CT perfusion imaging can reflect angiogenic activity, but no significant correlation is found between them.