Correlation Study between Spiral CT Perfusion Imaging and Angiogenesis in Esophageal Carcinoma

Objective To evaluate the correlation between spiral CT perfusion imaging and angiogenesis in esophageal carcinoma.Materials and Methods Multi-detector spiral CT perfusion scan was performed in 50 patients with esophageal carcinoma.The relationship of the CT perfusion imaging parameters,including blood volume(BV),blood flow(BF),mean transit time(MTT),and permeability surface(PS),with MVD and expressions of VEGF were analyzed.Results In 50 cases,the VEGF positive expression rate was 62%(31/50),and the negative expression rate was 38%(19/50).The mean MVD of VEGF-positive group were significantly higher than those of negative group(P0.05).CT perfusion parameter BF values and MVD count were positively correlated(P0.05).The correlation between BV,PS values and MVD count were more significantly positive correlated(P0.01).There was no statistical correlation between MTT values and MVD count(P0.05).The PS value and VEGF expression were positively correlated(P0.05).There was no statistical correlation between BF,BV,MTT values and VEGF expression(P0.05).Conclusion CT perfusion parameters can reflect not only the angiogenesis of esophageal carcinoma of the MVD,but also the expression of VEGF,indicating that CT perfusion parameters can be used as an assessment of tumor angiogenesis in vivo.