Association of the lipoprotein lipase S447X and HindIII polymorphisms with coronary heart disease

Objective To investigate the association of the lipoprotein lipase S447X and HindⅢ polymorphisms with coronary heart disease.Methods:We addressed this issue in a case-control study where 249 subjects with angiographically documented coronary artery disease and 167 subjects without CHD (excluded by coronarography).Plasma lipids were measured enzymatically in an MERCKMEGA analyzer.Restriction fragment length polymorphism (RFLP)analysis was performed to screen the LPL S447X and HindⅢ polymorphisms.Results:No significant difference was found in the frequencies of LPL S447X and HindⅢ genotype and alleles between controls and CHD patients(P0.05).But when the subjects were divided into TG1.7mmol/L group and TG≥1.7mmol/L group,the frequencies of SX/XX genotype and X allele in the former were higher than that in the latter (P0.05).And when TG1.7mmol/L,the plasma lipids (exclude sLDL)were significant difference between SS group and SX/XX group (P0.05).Conclusion:No significant difference was found in the frequencies of S,X,H+,H- alleles between controls and CHD patients.LPL S447X and HindⅢ polymorphisms were not independent risk factors of CHD,but S447X gene variant affects profiles of blood lipids,which will decelerate the development of CHD.