The interaction hepatic lipase gene promoter 250G/A polymorphism and coronary heart disease

Objective To explore the interaction between hepatic lipase gene promoter 250G/A polymorphism and coronary heart disease(CHD) in this area′s han population.Methods The genotype of the hepatic lipase gene promoter 250G/A were detected in 103 patients with CHD and 69 controls with polymerase chain reaction-restriction fragments length polymorphism(PCR-RFLP). The effect of the gene polymorphism on plasma lipids and apoproteins was also studied.Results No significant difference was found in the frequencies of alleles and the genotypes between the coronary heart disease and healthy elders.The significant difference was found in the serum high-density ipoprotein cholesterol levels and apoprotein A1 (P0.05). In the coronary heart disease′s genetype with a allele(GA and AA genotype),The apoA1 levels (1.20±0.31) g/L were lower than those in healthy elders(1.49±0.23) g/L,and the HDL-C levels (1.30±0.31) mmol/L were higher than those in the coronary heart disease without a allele(1.16±0.32) mmol/L.Multivariate logistic regression analysis showed that trilycerides was a risk factor for CHD,and apoA1 might be a protective factor.It also showed genotype with a allele is not a risk factor for CHD.Conclusion The hepatic lipase gene promoter 250G/A polymorphism is related with the level of plasma lipids in the CHD.