The clinical observation of intravitreal injection of Bevacizumab combined with trabeculectomy and panretinal photocoagulation for the treatment of neovascular glaucoma

Objective:To observe the clinical effect of intravitreal injection of Bevacizumab combined with trabeculectomy and panretinal photocoagulation for the treatment of neovascular glaucoma(NVG).Methods:21 cases(21 eyes) of NVG were managed with intravitreal Bevacizumab combined with trabeculectomy(7-10 days after injection).And panretinal photocoagulation when the anterior chamber were formed.Results:The average follow-up period was 11 months,visual acuity remained unchanged in 17 cases and slightly increased in 4 cases.Iris neovascularization was disappeared in 16 cases 3 days after injection.In the other 5 cases it was regressed and disappeared in 5-7 days.After 1,3,6 months the average intraocular pressures(IOP) were(16.70 ±2.01) mm Hg,(17.20±1.85) mm Hg,(20.50±2.03) mm Hg respectively,which had significant difference compared with preoperative IOP(P0.05).The IOP was controled in 19 cases.In the other 2 cases it was closed to normal added with Timolol.Headache and eye expansion were disappeared in all the cases.Conclusion:Intravitreal Bevacizumab has a positive effect in the treatment of neovascular glaucoma.Intravitreal injection of Bevacizumab combined with trabeculectomy and panretinal photocoagulation is effective for the treatment of NVG.