INVESTIGATION ON IATROGENIC RISK FACTORS OF DRUG RESISTANCE OF PSEU-DOMONAS AERUGINOSA IN HOSPITAL INFECTION TO IMIPENEM

[Obsjective] To identify the iatrogenic risk factors of drug resistance of Pseudomonas aeruginosa in hospital infection to imipenem. [Methods] From January 2005 to December 2007, a retrospective case-control study was developed concerning patients who had hospital infection caused by Pseudomonas aeruginosa. Patients with imipenem -resistant Pseu-domonas aeruginosa infections were designated as case patients, and control patients were those with imipenem -susceptible Pseudomonas aeruginosa. Variables investigations included hospitalization time, the number of antibiotics, co-infection, using imipenem time, prior imipenem, piperacillin or piperacillin / tazobactam, the third or forth generation cephalosporin, fluro-quinolone, aminoglycoside, macrolides, glycopeptide therapy, using hormone, invasive operation. [Results] Hospitalization time, the number of antibiotics, co-infection, using imipenem time, prior imipenem, piperacillin or piperacillin / tazobactam, the third or forth generation cephalosporin, fluroquinolone, aminoglycoside, glycopeptide therapy, invasive operation were the iatrogenic risk factors of imipenem -resistant Pseudomonas aeruginosa in hospital infection. [ Conclusions] To reduce the imipenem-resistance in Pseudomonas aeruginosa, limiting the use of imipenem and rational use of antibiotics according to the drug susceptibility test are very important. Strict disinfection and isolation must be executed to prevent the spread and field planting of imipenem-resistant Pseudomonas aeruginosa.