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Determination of tanshinone IIA in tongmai Pill by HPLC

Bin Li

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Abstract

Objective: To Establish the HPLC method to measurese the Tongmai Pill inside Tanshinone ⅡA contain , then control the pill′s inside quantity of Tongmai pill. Methods: Tanshinone ⅡA was extracted by Ultrasonic waves and then determined by HPLC. KromasilC18 column(250×4.6mm,5 μm;was utilized,the mobile phase with a flow rate of 1.2ml/min was methane-water (80:20;,the detection wavelength was 268nm. Results: The good linearity of the Tanshinone ⅡA was from 0.16～0.48 μg,r=0.9999 .The average recovery was 100.05% and RSD was 2.98%. Conclusion: This method was simple, accurate and could be used for controlling the product quality of the Tongmai Pill effectively.

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What this paper is about

Objective: To Establish the HPLC method to measurese the Tongmai Pill inside Tanshinone ⅡA contain , then control the pill′s inside quantity of Tongmai pill. Methods: Tanshinone ⅡA was extracted by Ultrasonic waves and then determined by HPLC. KromasilC18 column(250×4.6mm,5 μm;was utilized,the mobile phase with a flow rate of 1.2ml/min was methane-water (80:20;,the detection wavelength was 268nm. Results: The good linearity of the Tanshinone ⅡA was from 0.16～0.48 μg,r=0.9999 .The average recovery was 100.05% and RSD was 2.98%. Conclusion: This method was simple, accurate and could be used for controlling the product quality of the Tongmai Pill effectively.

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Available abstract

Objective: To Establish the HPLC method to measurese the Tongmai Pill inside Tanshinone ⅡA contain , then control the pill′s inside quantity of Tongmai pill. Methods: Tanshinone ⅡA was extracted by Ultrasonic waves and then determined by HPLC. KromasilC18 column(250×4.6mm,5 μm;was utilized,the mobile phase with a flow rate of 1.2ml/min was methane-water (80:20;,the detection wavelength was 268nm. Results: The good linearity of the Tanshinone ⅡA was from 0.16～0.48 μg,r=0.9999 .The average recovery was 100.05% and RSD was 2.98%. Conclusion: This method was simple, accurate and could be used for controlling the product quality of the Tongmai Pill effectively.

Key concepts: Chromatography, High-performance liquid chromatography, Pill, Medicine, Chemistry, Pharmacology

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