Importance of C-reactive protein detection to patients with acute coronary syndrome

Objective We assessed the levels of C-reactive protein(CRP) in patients with acute coronary syndrome (ACS), compared with no ACS and sought to test whether CRP was associated with clinical acute coronary syndrome. Methods Ultrasensitive immunoassay (rate nephelometry with the Beckman Immunochemistry Systems) was used to measure CRP levels of 91 patients with ACS and 194 patients with no-ACS. Results Compared with no-ACS group 〔(3.89±7.14)mg/L(SE 0.51, n=194)〕,CRP levels were higher in ACS group 〔(18.50±23.98)mg/L(SE 2.51, n=91)〕 (P0.01). CRP levels were higher for patients with acute phase of AMI 〔(19.01±24.02)mg/L〕 and UAP 〔(17.95±24.10)mg/L〕.Compared with healthy volunteers 〔(3.03±3.19)mg/L〕, CRP levels in patients with healing phase of AMI 〔(5.93±13.07)mg/L〕, old myocardial infarction (OMI) 〔(4.57±8.27)mg/L〕 and SAP 〔(3.94±7.50)mg/L〕 were mildly higher, and they were similar to each other in statistical analysis. Using Logistic regression, CRP was a potential determinant of ACS (OR=1.65). Conclusion These results suggested that CRP has a strong association with ACS, and CRP was a risk factor of ACS, but did not support the hypothesis that CRP was a potential determinant of OMI and stable angina pectoris(SAP).