Comparison of therapeutic efficiency of seretide plus montelukast and seretide only on patients with severe persistent asthma

Objective To compare the efficiency of seretide plus montelukast and seretide only on patients with severe persistent asthma. Methods Fifty patients with severe persistent asthma were randomly divided into two groups treated with seretide plus montelukast or seretide only for 12 weeks. The pulmonary function and clinical symptom before and after treatment were observed in two groups. Results The forced expiratory volume in 1 second (FEV1) after treatment improved significantly in the both groups (P0.01). The improved rate of FEV1 and FEV1% in the predicted value in the group plus montelukast was significantly higher than that in the group without montelukast at week 4 after treatment (P0.05). The symptom score in the group plus montelukast were significantly lower than that in the group without montelukast (P0.01). Conclusion The clinical improvement appears more rapidly in treatment by seretide plus montelukast than by seretide only.