Triple therapy with Rabeprazole,Amoxicillin and Sucralfate for eradication of Helicobacter pylori in duodenal ulcer disease

OBJECTIVE To evaluate a new triple therapy with Rabeprazole,Amoxicillin and Sucralfate for the eradication of Helicobacter pylori(HP) infection and the efficacy on healing of duodenal ulcer.METHODS 95 patients with active duodenal ulcer and HP infection proven by both rapid urease test and ()~(14)C-urea breath test were randomly divided into 2 groups.Group A treated with Rabeprazole 0.01 g(qd) plus Amoxicillin 1 g(bid) and Sucralfate 1 g(qid) for two weeks. Group B treated with Rabeprazole 0.01 g(qd) plus Amoxicillin 1 g(bid) and Clarithromycin 0.5 g(bid) for two weeks.The eradication rates of HP and the healing rates of duodenal ulcer were evaluated by the second endoscopy and()~(14)C-urea breath test on the 28th day after completion of the treatment.RESULTS The eradication rates of HP in group A and group B were 91.5% and 93.8%,respectively.There was no statistically significant difference between the two groups(P(0.05).)Although the ulcer healing rates in group A(93.6%)was higher than that in group B(89.6%),there was no statistically significant difference between them(P0.05).CONCLUSION Two-week triple therapy with Rabeprazole,Amoxicillin and Sucralfate is highly effective,safe and well-tolerated treatment for eradication of HP infection.