Study on the Pharmacokinetics of Glipizide in Human

Objective To study the pharmacokinetics and relative bioavailability of glipizide in human.Methods The plasma concentrations of 10 subjects were determlned by HPLC after 5.0 mg single dosage glipizide capsules and tablets were taken orally and crossly.The results were fitted with MC-PKP programm to get pharmacokinetie parameters.Then the relative bioavailability of capsule was caculated.Results The pharmacokineties parameters of capsule were as following,Cmax 456 ng/mL,Tmax 3.0 h,AUC 2 335 ng/(mL·h).Alove parameters of two preparations had no significant difference by double single t-test and 1～2α confidence in terval analysis.The relative bioavailability of glipizide capsule was(103±4)%.Conclusion The plasma concentration of glipizide capsule attach peak in(2.95±0.6)h,its peak concentration might be(456±60)ng/mL.Capsule and tablet of glipizide are bioequivolent preparations.