Clinical research on patients of diabetic peripheral neuropathy treated with Tangluoning

Objective: To observe the therapeutic effects and antioxidative effect of Tangluoning(TLN) on diabetic peripheral neuropathy(DPN).Methods: 210 DPN patients who were confirmed to the diagnostic criteria were randomly divided into the treatment group(105 patients) and control group(105 patients).On the basis of routine treatment,the patients in treatment group were given TLN.The patients in control group were given methycobal.The changes of symptoms,nerve conductive velocity and the content of malonaldehyde(MDA),the activity of superoxide dismutase(SOD) were observed in both groups.Results: The total effective rate of treatment group was 89.9%,which was obviously superior to that in control group(71.4%)(P0.05).There were significant differences in the improvement of nerve conductive velocity between two groups(P0.05).After treatment,MDA content decreased significantly and the level of SOD increased significantly in both groups(P0.05),oxidative stress reactions of patients in both two groups were significantly improved and the effect of treatment group was superior to that of control group,the difference was significant(P0.05).There were no obvious side effects during the treatment.Conclusion: TLN could obviously improve therapeutic effect on DPN by protecting against oxidative stress.