Effect of parecoxib sodium on postoperative PCIA analgesia with fentanyl after thoracic surgery

Objective To evaluate the analgesic effect and safety of parecoxib sodium on postoperative patient-controlled intravenous analgesia(PCIA)with fentanyl after thoracic surgery.Methods Sixty patients with ASA Ⅰ or Ⅱ undergoing thoracic surgery were randomly divided into three groups with 20 cases each.Group Ⅰ received parecoxib sodium 40 mg 15 min before operation,and group Ⅱ received parecoxib sodium 40 mg at the time of skin suture,and group Ⅲ received saline.PCIA with fentanyl was given to all patients.The scorings of VAS pain,HR,MAP at 2,8,24,48 h after surgery,24 h fentanyl consumption and side effects were recorded.Results The VAS scorings of pain in the groups Ⅰ and Ⅱ were lower than those in the group Ⅲ at 8 and 24 h(P0.05).The 24 h fentanyl consumption in the group Ⅰ [(0.53±0.02)mg] and group Ⅱ [(0.55±0.01)mg] were significantly lower than the group Ⅲ [(0.72±0.02)mg](P0.05).The overall incidence of side effects in the group Ⅰ and group Ⅱ were significantly lower than those of group Ⅲ(P0.05).Conclusion Parecoxib sodium can improve the outcomes of PCIA with fentanyl and reduce the incidence of postoperative adverse reactions without affecting cardiovascular function,and can be used safely for thoracic surgery.