Influence of preoperative injection of parecoxib sodium on PCIA with fentanyl in man

Objective To study the effect of patient-controlled intravenous analgesia(PCIA) with fentanyl.Methods Sixty patients undergoing the removal of internal fixation of the lower extremity were randomized to three groups with 20 cases each.The patients in groupⅠwere injected intravenously parecoxib sodium 40 mg 30 min before operation,which was given at the end of operation in group Ⅱ.The patients in group Ⅲ were not given as the controls.All patients received PICA with fentanyl.The analgesic effect was observed by VAS at 8,24,and 48 h after surgery.The fentanyl consumption and adverse responses were recorded as well.Results Analgesia was satisfectory in all cases.VAS points at 8 and 24 h after operation were significantly lower in groupⅠ than those in group Ⅱ(P0.05),which were all lower than those in group Ⅲ(P0.05).The consumption of fentanyl of group Ⅲ was significantly greater than that in group Ⅰ or group Ⅱ \[(0.43±0.08) mg vs.(0.30±0.07) mg or (0.34±0.09) mg\] (P0.05).There was no significant difference in adverse responses among three groups during analgesia.Conclusion Preoperative injection of parecoxib sodium may improve the outcomes of PCIA with fentanyl and reduce comsumption of fentanyl in the patients underwent removal of internal fixation.