Analgesic Effects of Parecoxib after Abdominal Cancer Operation

Objective: To study the analgesic effects of parecoxib in patients after abdominal cancer surgery with general anesthesia. Methods: Forty-five patients accepting abdominal cancer operation with general anesthesia were randomly divided into three groups( n = 15). All the patients in groupⅠ were given 40 mg parecoxib by intravenous injection in 30 min before the surgery,patients in groupⅡ received 40 mg parecoxib in 30 min before the end of the surgery; group Ⅲ was the control group. Every patient received a loading dose of 0. 05 mg / kg dezocine in 45 min before the end of the surgery, and patient-controlled intravenous analgesia( PCIA) with 0. 75 mg / kg dezocine was carried out after the operation. The visual analog scale( VAS) scores in 0. 25,2,4,8 and 24 h after operation and Remesay scores were recorded in 0. 25 h after operation. The number of using times of PCIA and adverse reactions,such as nausea,vomiting,urinary retention,bleeding,skin itching,fever and so on in 48h after operation were recorded. Results: VAS was significantly higher in group Ⅱthan that in groupⅠ( P 0. 05) in 0. 25 h and 2 h after surgery; In 0. 25,2,4,8 and 24 h,VAS was significantly higher in group Ⅲ than that in groupⅠand group Ⅱ( P 0. 05). Remesay score was significantly higher in groupⅠand group Ⅱthan that in group Ⅲ( P 0. 05) at 0. 25 h and 2 h. The number of using times of PCIA was significantly higher in group Ⅲ than that in groupⅠand groupⅡ( P 0. 05). The incidences of nausea,vomiting,urinary retention and fever in group Ⅲ were significantly more than those in groupⅠand group Ⅱ( P 0. 05). Conclusions: Parecoxib has exact analgesic effects after abdominal cancer surgery with general anesthesia,which can reduce the number of using times of dezocine PCIA and adverse reaction rate.