Surveillance of resistance to imipenem in Pseudomonas aeruginosa and its pan-drug resistance

Objective To investigate the clinical distribution,risk fators and antimicrobial resistance of Pseudomonas(P.)aeruginosa to imipenem and its pan-drug resistance for rational use of antimicrobials.Methods The susceptibility test results of P.asaeruginosa isolated from 2006-2008 were analyzed retrospectively.Results The resistance rates of P.aeruginosa to imipenem were 6.3%,20.93% and 38.04% respectively,pan-drug resistance were 0.45%,0.46% and 4.35% respectively in 2006-2008.During these years,imipenem-resistant P.aeruginosa had the increased resistance to other 14 kinds of common used antibiotics.In 2008,except amikacin(the drug-resistance rate 21.43%),the resistance rate of the other drugs reached up to over 60%.P.aeruginosa resistant to imipenem mainly distributed in ICU and and gerontologic department.Conclusion The resistance rates to imipenem and pan-resistance were increased obviously in our hospital during 2006-2008.Doctors should pay more attention to analyze the bacterial resistance profile.Amikacin is the most active agents against the P.aeruginosa isolates