Effect of tetrandrine and albendazole on Echinococcus multilocularis infection in mice

Aim To firstly report the effect of tetrandrine(Tet)on experimental mice infected with Echinococcus multilocularis and synergistic effect of co administration with albendanzole(ABZ) Method The experiment was devided into two parts In the first part,the killing action of tetrandrine against E multilocularis protoscolices was observed in vitro In the second part,the animal experiment was devided into four groups,including single tetrandrine,single albendanzole,combination of the two drugs and cotrol group Results After treating 90 days,the mice were taked the blood from post eyeball and dissected The major judging criteria included cyst wet weight,inhibition rate,histopathological changes of cyst both microscopically and electoron microscopically and pathological grading The experimental outcome indicaded that the single tetrandrine and the combination had obviously effect against growing of E multilocularis cyst(Inhibition rate was 44 55% and 80 82% respectively) Conclusions The experiment indicates that tetrandrine against E multilocularis has inhibiting effect Especially the combinative therapy of the two drugs on E multilocularis have strong inhibitive action This indicates that tetrandrine canstrengthen albendazole's effect against E multilocularis and that two drugs have synergistic actioin