Pathohistological changes on efficacy of liposomal albendazole against echinococcus multilocularis infection in experimental mice

Objective: According to comparative animal experiments between the groups for new formulation(liposomal albendazole)and the albendazole tablets, anti echinococcus multilocularis effect has been evaluated objectively between oral path and intraperitoneal path. Methods: 225 NIH mice with echinococcus multilocularis infection were given albendazole orally and intraperitoneally (37.5 mg、37 mg and 150 mg /kg) for 10 weeks. In order to make statistical analysis, histopathological changes were divited into three levels such as normal、degeneration and necrosis. Result: albendazole and its metabolic product had effect in damaging the echinococcus multilocularis cysts and inhibiting the E.M protoscoleces multiplication. Conculusion: Groups treated by both oral irrigation path and intraperitoneal injection had more effect than that by oral tablets administration alone.