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2009•Unpublished venueRequires access

Expression and significance of Bcl-2 and Caspase-3 in colorectal carcinoma

Han Guang-sen

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Abstract

Objective:To study the expression and significance of Bcl-2 and Caspase-3 in colorectal carcinoma.Methods:SP immunohistochemical technique was used to examine the expression of Bcl-2 and Caspase-3 in 42 cases of colorectal carcinoma and 25 cases of normal colorectal mucosa.Results:The expressions of Bcl-2 and Caspase-3 were significantly different in different pathological grading(P0.05) and were no significantly different in stages of Dukes and lymphnode metastasis(P0.05).Conclusion:The expressions of Bcl-2 and Caspase-3 may be closely correlated to the occurrence and development of colorectal carcinoma.Detecting the expression of Bcl-2 and Caspase-3 in colorectal carcinoma is useful for the early diagnosis of colorectal carcinoma and evaluation of the prognosis.

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Objective:To study the expression and significance of Bcl-2 and Caspase-3 in colorectal carcinoma.Methods:SP immunohistochemical technique was used to examine the expression of Bcl-2 and Caspase-3 in 42 cases of colorectal carcinoma and 25 cases of normal colorectal mucosa.Results:The expressions of Bcl-2 and Caspase-3 were significantly different in different pathological grading(P0.05) and were no significantly different in stages of Dukes and lymphnode metastasis(P0.05).Conclusion:The expressions of Bcl-2 and Caspase-3 may be closely correlated to the occurrence and development of colorectal carcinoma.Detecting the expression of Bcl-2 and Caspase-3 in colorectal carcinoma is useful for the early diagnosis of colorectal carcinoma and evaluation of the prognosis.

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Available abstract

Objective:To study the expression and significance of Bcl-2 and Caspase-3 in colorectal carcinoma.Methods:SP immunohistochemical technique was used to examine the expression of Bcl-2 and Caspase-3 in 42 cases of colorectal carcinoma and 25 cases of normal colorectal mucosa.Results:The expressions of Bcl-2 and Caspase-3 were significantly different in different pathological grading(P0.05) and were no significantly different in stages of Dukes and lymphnode metastasis(P0.05).Conclusion:The expressions of Bcl-2 and Caspase-3 may be closely correlated to the occurrence and development of colorectal carcinoma.Detecting the expression of Bcl-2 and Caspase-3 in colorectal carcinoma is useful for the early diagnosis of colorectal carcinoma and evaluation of the prognosis.

Key concepts: Colorectal cancer, Pathological, Medicine, Grading (engineering), Immunohistochemistry, Carcinoma, Clinical significance, Metastasis

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