Expression of anti-apoptotic gene bag-1 and bcl-2 in colorectal cancer and their interations

Objective To investigate the expression of bag-1 and bcl-2 in colorectal cancer and evaluate their clinical significance.Methods The expression levels of bag-1 and bcl-2 were detected by using immunohistochemical Streptavidin-Biotin-Peroxidase Complex (SABC) method in 64 samples of colorectal cancer tissues,10 normal colorectal tissues.Results bag-1 was positively related to the tumour grade,distant metastasis,stages of Dukes and prognosis,but not to the pathological cell types,tumour diameter,depth of invasion and lymph node metastasis.bcl-2 was not correlated to these clinicopathologic factors.There was a positive correlation between bag-1 and bcl-2 (r=0.475).Conclusion There is overexpression of bag-1 and bcl-2 protein in colorectal cancer.bag-1 and bcl-2 might serve as a biomarker to diagnose the early colorectal cancer.