Effect of Combination Inhaled Tiotropium Bromide and Salmeterol/Fluticasone in Chronic Obstructive Pulmonary Disease

Objective To investigate the therapeutic effects of combined inhalation of Tiotropium Bromide and Salmeterol/Fluticasone propionate in chronic obstructive pulmonary diseases(COPD).Methods 128 cases of moderate to severe stable COPD were randomly divided into 4 groups: the combined treatment group were treated with Tiotropium Bromide and Salmeterol /Fluticasone;the Tiotropium Bromide group were treated with Tiotropium Bromide;the Salmeterol /Fluticasone were treated with Salmeterol /Fluticasone;the control group was given routine treatment.Changes in patient lung function,acute episode and adverse reaction were observed.Results At the end of treatment,compared with blank group,FEV1 improved significantly,the number of acute episodes decreased significantly and no significant increase in adverse reactions in all three treatment groups.Conclusion Tiotropium Bromide and salmeterol/fluticasone propionate combined inhaled treatment in COPD patients can significantly improve lung function and reduce acute episodes,while no significant increase in adverse events was observed.The combined treatment seems worthy of consideration for clinical application.