Comparative study of duloxetine combined with cognitive-behavioral therapy in the treatment of panic disorder

Objective To investigate the clinical efficacy of duloxetine combined with cognitive-behavioral therapy(CBT) in the treatment of panic disorder(PD) versus duloxetine monotherapy.Methods 60 patients with PD were randomly divided into study group(31 cases,treated with duloxetine combined with CBT for 12 weeks) and control group(29 cases,treated with duloxetine monotherapy for 12 weeks).Hamilton anxiety scale(HAMA),clinical global impression-disease severity(CGI-SI) were used to assess the therapeutic effect at baseline and the end of the 2nd,4th,8th,12th week of the treatment.The treatment emergent symptom scale(TESS) was used to assess the side effect in the treatment.Results Scores of HAMA and CGI-SI at each interviewpoint decreased significantly when compared with those at baseline(P0.05 or P0.01).The decrease in study group was more significant than that in control group(P0.05 or P0.01).Adverse reactions in both groups were mild.Conclusion Duloxetine combined with CBT is better than duloxetine monotherapy for patients with PD.