A Clinical Study of Milrinone on Heart Failure

Objective: To observe the clinical effect and security of milrinone in the treatment of heart failure.Method: Selected 105 patients treated in our department from Jan.2007 to Jun.2011 and they were randomly divided into two groups according to the hospital number,52 cases in the observation group and 53 cases in the control group.All patients received the routine treatment of diuretics and oral taking of angiotensin converting enzyme,while patients in the observation group received the treatment of milrinone,and those in the control group received the treatment of sodium nitroprusside and dopamine.Compared the indicators of heart rate(HR),mean artery pressure(MAP) and left ventricular function on patients in the observation group before and after the treatment;meanwhile compared the curative effect between the observation group and control group.Result: The total effective rate of patients in the observation was 71.15%,while the one of patients in the control group was 52.63%,There's statistically significant difference(P0.05);there was significant improvements on the cardiac output(CO),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),and ratio of the E peak and A peak velocities(E/A) after the treatment than ones before the treatment,with the statistical difference(P0.05);there was no significant difference in HR and MAP of patients in the observation group before and after the treatment(P0.05).Conclusion: There is a significant clinical effect of milrinone in the treatment of heart failure.It should pay attention to the dosage and medication time during the treatment to maximally guarantee the security of the medication.It can be one of the most ideal treatments for heart failure.