Study on effect of Benazepril and Telmisartan in the treatment of patients with patients with early diabetic nephropathy

Objective To observe the efficacy of Benazepril combined with Telmisartan in the treatment of patients with early diabetic nephropathy,and to provide strong theoretical support for the clinical treatment of diabetic nephropathy.Methods 62 patients diagnosed early diabetic nephropathy in Fushun Central Hospital from January 2010 to January 2012 were selected and divided into a study group of 32 patients confirmed application Benazepril Telmisartan therapy treatment,the control group of 30 patients confirmed application Benazepril treatment,total treat ment for 12 weeks.The clinical efficacy rate was observed after treatment for 12 weeks.And the urinary albumin ex cretion rate(UAER) and fasting plasma glucose(FPG) and 2-hour postprandial blood glucose(2 h PBG),blood urea nitrogen(BUN),serum creatinine(Scr) changes were observed after treatment for 3,6 and 12 months.Results After 12 weeks of treatment,the markedly effective rate of study group was 56.25%,the total effective rate of study group was 93.75%,markedly effective rate of the control group was 40.00%,the total effective rate of the control group 70.00%,the markedly effective rate had no significant difference between two groups(P 0.05).The difference was significant of total effective rate of the two groups(P 0.05).After treatment for 3,6 and 12 months,FBG,2 h PBG of the study group and the control group decreased than before treatment,but the differences were not significant(P 0.05).And after treatment for 3,6,and 12 months,differences of FBG,2 h PBG of the two groups at different time points were not statistically significant(P 0.05).After treatment for 3,6 and 12 months,UAER of the study group and the con trol group compared with pre-treatment significantly reduced,the difference was significant(P 0.05).The UAER level of the study group after treatment for 3,6 and 12 months,compared with the control group,the UAER of the study group significantly decreased,the difference was significant(P 0.05).The Scr of the study group significantly reduced after treatment for 3,6 and 12 months and reduced than before treatment,the difference was extremely signifi cant(P 0.05).Scr level of the control group after treatment 3,6 and 12 months reduced than before treatment,the difference was significant(P 0.05).Scr of the study group after treatment 3,6 and 12 months compared with the control group decreased significantly,and the difference was significant(P 0.05).Conclusion Benazepril and Telmisartan in the treatment of early diabetic nephropathy has a synergistic effect to reduce urinary protein excretion,which plays a role to protect kidney function.