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Correlation of MMP-9 and nm23-H1 expression to invasion and metastasis in cholangiocarcinoma

Haoliang Zhao

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Abstract

Objective To detect the expression of MMP-9 and nm23-H1 in cholangiocarcinoma,and to explore their correlation to invasion and metastasis in cholangiocarcinoma. Methods The expression of MMP-9 and nm23-H1 were detected with immunohistochemistry(PV-9000) in 35 samples with invasion and metastasis and 25 samples without invasion and metastasis. Results In invasion and metastasis samples,the positive rates of MMP-9 and nm23-H1 were 71.4%(25/35) and 25.7%(9/35),respectively.In samples without invasion and metastasis,the positive rates were 40.0%(10/25) and 60.0%(15/25),respectively.The expression of MMP-9 was positively related to invasion and metastasis in cholangiocarcinoma(P0.05),but negatively related to nm23-H1 expression(P0.01).The expression of nm23-H1 was negatively related to invasion and metastasis in cholangiocarcinoma(P0.01). Conclusion MMP-9 and nm23-H1 may be useful diagnostic parameters for invasion and metastasis in cholangiocarcinoma.

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Objective To detect the expression of MMP-9 and nm23-H1 in cholangiocarcinoma,and to explore their correlation to invasion and metastasis in cholangiocarcinoma. Methods The expression of MMP-9 and nm23-H1 were detected with immunohistochemistry(PV-9000) in 35 samples with invasion and metastasis and 25 samples without invasion and metastasis. Results In invasion and metastasis samples,the positive rates of MMP-9 and nm23-H1 were 71.4%(25/35) and 25.7%(9/35),respectively.In samples without invasion and metastasis,the positive rates were 40.0%(10/25) and 60.0%(15/25),respectively.The expression of MMP-9 was positively related to invasion and metastasis in cholangiocarcinoma(P0.05),but negatively related to nm23-H1 expression(P0.01).The expression of nm23-H1 was negatively related to invasion and metastasis in cholangiocarcinoma(P0.01). Conclusion MMP-9 and nm23-H1 may be useful diagnostic parameters for invasion and metastasis in cholangiocarcinoma.

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Available abstract

Objective To detect the expression of MMP-9 and nm23-H1 in cholangiocarcinoma,and to explore their correlation to invasion and metastasis in cholangiocarcinoma. Methods The expression of MMP-9 and nm23-H1 were detected with immunohistochemistry(PV-9000) in 35 samples with invasion and metastasis and 25 samples without invasion and metastasis. Results In invasion and metastasis samples,the positive rates of MMP-9 and nm23-H1 were 71.4%(25/35) and 25.7%(9/35),respectively.In samples without invasion and metastasis,the positive rates were 40.0%(10/25) and 60.0%(15/25),respectively.The expression of MMP-9 was positively related to invasion and metastasis in cholangiocarcinoma(P0.05),but negatively related to nm23-H1 expression(P0.01).The expression of nm23-H1 was negatively related to invasion and metastasis in cholangiocarcinoma(P0.01). Conclusion MMP-9 and nm23-H1 may be useful diagnostic parameters for invasion and metastasis in cholangiocarcinoma.

Key concepts: Metastasis, Matrix metalloproteinase, Immunohistochemistry, Pathology, Medicine, Cancer research, Biology, Internal medicine

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